1. to turn away in feeling or affection; make unfriendly or hostile; alienate the affections of.
2. to remove to or keep at a distance.
3. to divert from the original use or possessor.
4. separated and living apart from one’s spouse.
Etymology: from Middle French, Old French estranger; cognate with Portuguese estranhar, Spanish estrañar, Italian straniare < Mediaeval Latin exstrāneāre, “to treat as a stranger”.
[Jérémie Fleury - Edward Scissorhands]